2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. ATP Synthase
  5. ATP Synthase Agonist

ATP Synthase Agonist

ATP Synthase Agonist (1):

Cat. No. Product Name Effect Purity
  • HY-175839
    PROTAC EGFR degrader 15
    		Agonist
    PROTAC EGFR degrader 15 is a Pomalidomide (HY-10984)-based Gefitinib (HY-50895) EGFR PROTAC degrader. PROTAC EGFR degrader 15 triggers EGFR degradation via ubiquitin-proteasome-dependent proteolysis and autophagy-lysosome activation pathways. PROTAC EGFR degrader 15 targets ETFA to enhance ATP production. PROTAC EGFR degrader 15 significantly suppresses tumor growth in a Gefitinib-acquired resistant HCC-827 xenograft model. PROTAC EGFR degrader 15 can be used for the study of non-small cell lung cancer (NSCLC) (Pink: EGFR ligand (HY-W109039); Blue: CRBN ligand (HY-10984); Black: Linker (HY-W679737)).